SV119-gold nanocage conjugates: a new platform for targeting cancer cellsvia sigma-2 receptors

SV119-gold nanocage conjugates: a new platform for targeting cancer cells via sigma-2 receptors.

We have functionalized the surface of gold nanocages with SV119, a synthetic small molecule specific to sigma-2 receptors, and then demonstrated the capability of this new class of conjugates for targeting cancer cells.

Gold Nanocage-Photosensitizer Conjugates for Dual-Modal Image-Guided Enhanced Photodynamic Therapy

We have demonstrated that gold nanocage-photosensitizer conjugates can enable dual image-guided delivery of photosensitizer and significantly improve the efficacy of photodynamic therapy in a murine model. The photosensitizer, 3-devinyl-3-(1'-hexyloxyethyl)pyropheophorbide (HPPH), was noncovalently entrapped in the poly(ethylene glycol) monolayer coated on the surface of gold nanocages. The con...

Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling Running Title: Sigma-2 Conjugates Induce Cancer Selective Apoptosis

Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic

Cancer-selective drug delivery is an important concept in improving treatment while minimizing off-site toxicities, and sigma-2 receptors, which are overexpressed in solid tumors, represent attractive pharmacologic targets. Select sigma-2 ligands have been shown to be rapidly internalized selectively into cancer cells while retaining the capacity to deliver small molecules as drug cargoes. We u...

A New Fuzzy Method for Assessing Six Sigma Measures

Six-Sigma has some measures which measure performance characteristics related to a process. In most of the traditional methods, exact estimation is used to assess these measures and to utilize them in practice. In this paper, to estimate some of these measures, including Defects per Million Opportunities (DPMO), Defects per Opportunity (DPO), Defects per unit (DPU) and Yield, a new algorithm ba...